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The individual PhD research projects form the core of the doctoral programme.

They are each supervised by one of the Principal Investigators of BioToP, however, close collaboration with other research groups/PIs within this doctoral programme is foreseen. This will thus strengthen the multi-disciplinary character of this programme. In addition, short term research stays abroad (approx. 6 months) in the laboratories of international collaboration partners are planned.



List of ongoing PhD research projects sorted by department:

DEPARTMENT   SUPERVISOR PhD STUDENT
Department of Applied Genetics and Cell Biology      
Isolation and functional characterization of Nicotiana benthamiana papain-like cysteine proteinases   Lukas Mach Melanie Niemer
Antibody production in seed tissues: evaluating the subcellular deposition, N−glycan modification and functionality   Eva Stöger Stanislav Melnik
Artificial storage organelles for the optimal production of biopharmaceuticals in plants and plant cells   Eva Stöger Anna Hofbauer
       
Department of Biotechnology      
Generation and presentation of membrane protein targets using baculovirus surface display   Reingard Grabherr Monika Wilde
Influenza virus−like particles as antigen carrier platform for conserved influenza viral epitopes   Reingard Grabherr Miriam Klausberger
Directed evolution of CHO host and production cell lines   Johannes Grillari Eva Harreither
MicroRNOMics of CHO host and production cell lines   Johannes Grillari Vaibhav Jadhav
Influence of surface curvature on unfolding of proteins on nanoparticle   Alois Jungbauer Peter Satzer
Modelling of interactions in miRNA and gene expression and target validation   David Kreil Smriti Shridhar
Regulation of the expression of recombinant pentameric IgMs   Renate Kunert Veronika Chromikova
Cross−Species Comparison of Expression Systems   Renate Kunert Andreas Maccani
Regulation of heterologous protein production in relation to cell growth   Diethard Mattanovich Corinna Rebnegger
Interrelation of core metabolism with the production of heterologous proteins in yeast   Diethard Mattanovich Justyna Nocon
       
Department of Chemistry      
Receptor specificity of the H1 hemagglutinin of the H1N1 swine−origin influenza A virus (S-OIV)   Friedrich Altmann Laura Neumann
Yeast Cell Wall Characterisation   Gunda Köllensperger Evelyn Rampler
Human peroxidasins − new multidomain oxidoreductases in the vascular system   Christian Obinger Monika Soudi
Biocatalysis of chlorite dismutation − functional and structural studies on new peculiar heme enzymes of high practical relevance for bioremediation   Christian Obinger Stefan Hofbauer
New generations of monoclonal antibodies based on the Fc-fragment of IgG1 − loop engineering and library design of immunoglobulin domains   Christian Obinger Christoph Hasenhindl
Engineering the interface of Fab fragments   Christian Obinger Sylvia Dietrich
Functional studies on catalase-peroxidases and design of mechanism-based inhibitors   Christian Obinger Bernhard Gasselhuber
Expression cloning of immunomodulatory glycan−modifying enzymes in insect cells   Iain Wilson Simone Kurz
       
Department of Food Science and Technology      
Probing the active site of pyranose dehydrogenase − covalent attachment of the FAD and vicinity of the isoalloxazine   Dietmar Haltrich Michael Graf
Engineering of pyranose oxidoreductases for modified oxygen reactivity   Dietmar Haltrich Iris Krondorfer
Dagmar Brugger
Establishing platforms for the production of recalcitrant proteins for functional and structural studies   Dietmar Haltrich Georg Mlynek
Engineering of a novel fungal esterase by means of directed evolution and site-directed mutagenesis   Dietmar Haltrich Daniel Kracher
Evolution and engineering of pyranose dehydrogenase for biofuel cell applications   Dietmar Haltrich Christoph Gonaus
       
Department of Material Sciences and Process Engineering      
Contribution of enthalpy and entropy in molecular association   Chris Oostenbrink Balder Lai
Structure and dynamics of cellobiose dehydrogenase and cytochrome P450   Chris Oostenbrink Gabor Nagy
       
Department of NanoBiotechnology      
Assembly and interaction mechanisms of S−layer glycoproteins for applications in nanobiotechnology   Paul Messner Zoe Megson
Carbohydrate−active enzymes in S−layer protein glycosylation   Paul Messner Valentin Friedrich
Biochemical and Molecular Analysis of the Cell Wall Glyco(prote)ome of Lactobacillus buchneri   Paul Messner Eva Smolar
S−layer mediated display of customized glycans enabled by glycosylation engineering   Christina Schäffer Julia Anzengruber
Glycoprofiling of the oral pathogen Tannerella forsythia for identifying novel strategies in pathogenicity   Christina Schäffer Markus Tomek