select area select supervisor Area 1 Area 2 Area 3 Area 4 Altmann Borth Grabherr Grillari Haltrich Jungbauer Kunert Ludwig Mach Mattanovich Obinger Oostenbrink Steinkellner Stöger Wilson Projects of Area 3 - Expression systems and cell factories List of open PhD research projects: RESEARCH PROJECT SUPERVISOR PhD STUDENT Synthetic biology tools to control expression of multiple genes in a pathway Nicole Borth open Mechanisms of control of endogenous gene expression Nicole Borth open Extracellular micro vesicles and exosomes and their role in the insect cell-baculovirus expression system Reingard Grabherr open Inducible regulation of baculovirus genes involved in secretion and virus budding Reingard Grabherr open Cellular limitations of poor protein secretion in mammalian cells Renate Kunert open Impact of extrinsic production factors on mammalian cell production performance Renate Kunert open Control of glycolysis in Crabtree-negative and positive yeasts Diethard Mattanovich open Folding of recombinant bacterial RuBisCO Diethard Mattanovich open In planta engineering and functional activities of oligo-sialic acid Herta Steinkellner open Engineering and functional activities of polysialylated IgG antibodies Herta Steinkellner open Designed protein storage organelles and their uptake into target cells Eva Stöger open Modulating ER morphology and stress to boost recombinant protein accumulation Eva Stöger open List of ongoing PhD research projects: RESEARCH PROJECT SUPERVISOR PhD STUDENT Introduction of unnatural amino acids in recombinant proteins with the yeast Pichia pastoris Diethard Mattanovich Nora Tir Understanding the source of variation in protein N-glycosylation patterns of recombinant proteins generated in CHO cells Nicole Borth Nina Bydlinski Productivity optimisation of CHO cells by epigenome alterations Nicole Borth Peter Eisenhut Quantitative metabolic flux analysis in CHO cells Nicole Borth Diana Szeliova Change of the Global Methylation Pattern to Alter the Growth Phenotype of CHO-CellsBackground Nicole Borth Marcus Weinguny Establishment of a hyper-secreting eukaryotic protein production system as alternative cell factory for biotherapeutics Nicole Borth Michael Coats Cellular Mechanisms of Regulation Brigitte Gasser Sonakshi De Characterization of transcriptional regulatory proteins Brigitte Gasser Diane Barbay Rational systems design of protein-producing yeasts: eliminating metabolic limitations Brigitte Gasser David Pena Generation and presentation of membrane protein targets using influenza virus−like particles Reingard Grabherr Nika Lisa In silico guided humanization of antibodies Renate Kunert Linda Schwaigerlehner Defined gp140 trimers as HIV vaccine Renate Kunert Philipp Mundsperger Characterization of microbial methanol metabolism Diethard Mattanovich Domen Zavec Metabolic engineering of Pichia pastoris Diethard Mattanovich Thomas Gassler Enzyme scaffolding and cellular compartments for metabolic engineering endeavours Michael Sauer Bernd Albrecht Understanding molecular transport processes for improved metabolic engineering approaches Michael Sauer Dominik Jeschek Immunoglobulin E (IgE) and glycosylation Herta Steinkellner Laura Montero Morales Development of a seed-based strategy for the design of a mucosal vaccine against S. pneumoniae Eva Stöger Marc Tschofen Protein-liposome conjugates as novel HIV vaccine candidates Karola Vorauer-Uhl Ehsan Suleiman List of completed PhD research projects: RESEARCH PROJECT SUPERVISOR PhD STUDENT Understanding and controlling the expression of recombinant oligomeric immunoglobulins Renate Kunert Julia Hennicke Molecular engineering of baculoviral based protein expression in insect cells Reingard Grabherr Krisztina Koczka Genomic rearrangements in CHO producer cell lines Nicole Borth Inmaculada Hernandez-Lopez Engineering Pichia pastoris for antibody surface display Diethard Mattanovich Lina Heistinger Plant glyco-engineering towards synthesis of recombinant proteins with polysialylated N-glycans Herta Steinkellner Somanath Kallolimath Investigation and Enhancement of Growth Characteristics of Chinese Hamster Ovary Cells Nicole Borth Gerald Klanert Generation and presentation of membrane protein targets using baculovirus surface display Reingard Grabherr Monika Wilde Influenza virus−like particles as antigen carrier platform for conserved influenza viral epitopes Reingard Grabherr Miriam Klausberger Cross−Species Comparison of Expression Systems Reingard Grabherr Andreas Maccani Directed evolution of CHO host and production cell lines Johannes Grillari Eva Harreither MicroRNOMics of CHO host and production cell lines Johannes Grillari Vaibhav Jadhav Yeast Cell Wall Characterisation Gunda Köllensperger Evelyn Rampler Quantitative Metabolomics by LC–MS Gunda Köllensperger Karin Ortmayr Regulation of the expression of recombinant pentameric IgMs Renate Kunert Veronika Chromikova Powerful expression of recombinant proteins Renate Kunert Wolfgang Sommeregger Influence of amino acid sequence on growth and secretion of recombinant CHO cell lines Renate Kunert Patrick Mayrhofer Regulation of heterologous protein production in relation to cell growth Diethard Mattanovich Corinna Rebnegger Interrelation of core metabolism with the production of heterologous proteins in yeast Diethard Mattanovich Justyna Nocon Antibody production in seed tissues: evaluating the subcellular deposition, N−glycan modification and functionality Eva Stöger Stanislav Melnik Artificial storage organelles for the optimal production of biopharmaceuticals in plants and plant cells Eva Stöger Anna Hofbauer