Research Areas


 

Area 1: Structure-function analysis, engineering and design of proteins


  • Research on structure-function analysis of enzymes and pharmaceutical and regulatory proteins
  • Identification of minimal functional elements
  • Protein engineering and design
  • Design of novel functional ligands and inhibitors
  • Design, display and screening strategies of protein libraries for the development of novel functional proteins and therapeutics

PRINCIPAL INVESTIGATORS within this area are Haltrich, Ludwig and Obinger

Projects within this area



Area 2: Biosynthesis, post-translational modifications and trafficking of recombinant proteins


  • Protein biosynthesis and processing
  • Targeting and modification of proteins in host cells
  • Research on protein degradation in host cells as a basis for efficient production of complex proteins in higher eukaryotic systems
  • Development of suitable quality control procedures for protein therapeutics

PRINCIPAL INVESTIGATORS within this area are Altmann, Grillari, Mach and Wilson

Projects within this area



Area 3: Expression systems and cell factories


  • Expression strategies in major microbial, plant and animal host cells
  • Stress regulation
  • Molecular mechanisms and regulation of protein folding and secretion
  • Identification and elimination of bottlenecks in the production of new and complex proteins

PRINCIPAL INVESTIGATORS within this area are Borth, Grabherr, Kunert, Mattanovich, Steinkellner, Stöger

Projects within this area



Area 4: Bioinformatics and molecular modelling


  • Data bases and data mining
  • Computational genomics and proteomics
  • Molecular modelling and simulation techniques in protein (bio)chemistry
  • Computational chemistry for in silico target discovery and structure based drug design
  • Elucidation and prediction of biophysical properties of proteins
  • Design and simulation of large-scale protein purification methods

PRINCIPAL INVESTIGATORS within this area are Jungbauer and Oostenbrink

Projects within this area