Research Areas


 

Area 1: Structure-function analysis, engineering and design of proteins


  • Research on structure-function analysis of enzymes and pharmaceutical and regulatory proteins
  • Identification of minimal functional elements
  • Protein engineering and design
  • Design of novel functional ligands and inhibitors
  • Design, display and screening strategies of protein libraries for the development of novel functional proteins and therapeutics

PRINCIPAL INVESTIGATORS within this area are Obinger and Haltrich

Projects within this area



Area 2: Biosynthesis, post-translational modifications and trafficking of recombinant proteins


  • Protein biosynthesis and processing
  • Targeting and modification of proteins in host cells
  • Research on protein degradation in host cells as a basis for efficient production of complex proteins in higher eukaryotic systems
  • Development of suitable quality control procedures for protein therapeutics

PRINCIPAL INVESTIGATORS within this area are Altmann, Grillari, Mach and Wilson

Projects within this area



Area 3: Expression systems and cell factories


  • Expression strategies in major microbial, plant and animal host cells
  • Stress regulation
  • Molecular mechanisms and regulation of protein folding and secretion
  • Identification and elimination of bottlenecks in the production of new and complex proteins

PRINCIPAL INVESTIGATORS within this area are Borth, Grabherr, Kunert, Mattanovich, Steinkellner, Stöger

Projects within this area



Area 4: Bioinformatics and molecular modelling


  • Data bases and data mining
  • Computational genomics and proteomics
  • Molecular modelling and simulation techniques in protein (bio)chemistry
  • Computational chemistry for in silico target discovery and structure based drug design
  • Elucidation and prediction of biophysical properties of proteins
  • Design and simulation of large-scale protein purification methods

PRINCIPAL INVESTIGATORS within this area are Jungbauer and Oostenbrink

Projects within this area