Research Areas
Area 1: Structure-function analysis, engineering and design of proteins
- Research on structure-function analysis of enzymes and pharmaceutical and regulatory proteins
- Identification of minimal functional elements
- Protein engineering and design
- Design of novel functional ligands and inhibitors
- Design, display and screening strategies of protein libraries for the development of novel functional proteins and therapeutics
FACULTY MEMBERS within Area 1 are Haltrich, Hofbauer, Ludwig, Obinger, Peterbauer, Rüker, Schäffer and Traxlmayr.
Area 2: Biosynthesis, post-translational modifications and trafficking of recombinant proteins
- Protein biosynthesis and processing
- Targeting and modification of proteins in host cells
- Research on protein degradation in host cells as a basis for efficient production of complex proteins in higher eukaryotic systems
- Development of suitable quality control procedures for protein therapeutics
FACULTY MEMBERS within Area 2 are Altmann, Grillari, Mach, Strasser and Wilson
Area 3: Expression systems and cell factories
- Expression strategies in major microbial, plant and animal host cells
- Stress regulation
- Molecular mechanisms and regulation of protein folding and secretion
- Identification and elimination of bottlenecks in the production of new and complex proteins
FACULTY MEMBERS within Area 3 are Borth, Gasser, Grabherr, Kunert, Mattanovich, Steinkellner, Stöger and Vorauer-Uhl.
Area 4: Bioinformatics and molecular modelling
- Data bases and data mining
- Computational genomics and proteomics
- Molecular modelling and simulation techniques in protein (bio)chemistry
- Computational chemistry for in silico target discovery and structure based drug design
- Elucidation and prediction of biophysical properties of proteins
- Design and simulation of large-scale protein purification methods
FACULTY MEMBERS within Area 4 are Buyel, Jungbauer, Oostenbrink, Tscheliessnig and Zanghellini.