The individual PhD research projects form the core of the doctoral programme.

They are each supervised by one of the Principal Investigators of BioToP, however, close collaboration with other research groups/PIs within this doctoral program is foreseen. This will thus strengthen the multi-disciplinary character of this programme.

In addition, short term research stays abroad (approx. 6 months) in the laboratories of international collaboration partners are planned.


List of ongoing PhD research projects sorted by department:

DEPARTMENT   SUPERVISOR PhD STUDENT
Applied Genetics and Cell Biology      
Isolation and functional characterization of Nicotiana benthamiana serine proteinases involved in the degradation of recombinant proteins   Lukas Mach Alejandro Puchol Tarazona
Plant glyco-engineering towards synthesis of recombinant proteins with polysialylated N-glycans   Herta Steinkellner Somanath Kallolimath
Immunoglobulin E (IgE) and glycosylation   Herta Steinkellner Laura Montero Morales
Development of a seed-based strategy for the design of a mucosal vaccine against S. pneumoniae   Eva Stöger Marc Tschofen
Identification of Lewis a containing glycoproteins from Arabidopsis thaliana and characterization of their involvement in pathogen defence   Richard Strasser Gernot Beihammer
Analysis of structure−function relationships of monomeric and dimeric human IgA1 and IgA2 with defined N− and O−glycosylation   Richard Strasser Kathrin Göritzer
       
Department of Biotechnology      
Genomic rearrangements in CHO producer cell lines   Nicole Borth Inmaculada Hernandez-Lopez
Understanding the source of variation in protein N-glycosylation patterns of recombinant proteins generated in CHO cells   Nicole Borth Nina Bydlinski
Productivity optimisation of CHO cells by epigenome alterations   Nicole Borth Peter Eisenhut
Quantitative metabolic flux analysis in CHO cells   Nicole Borth Diana Szeliova
Change of the Global Methylation Pattern to Alter the Growth Phenotype of CHO-CellsBackground   Nicole Borth Marcus Weinguny
Generation and presentation of membrane protein targets using influenza virus−like particles   Reingard Grabherr Lisa Nika
Molecular engineering of baculoviral based protein expression in insect cells     Reingard Grabherr Krisztina Koczka
Engineering the interface of Fab fragments for the generation of bispecific antibodies   Johannes Grillari Maximilian Bönisch
Extracellular vesicle trafficking in aging   Johannes Grillari Madhu Bobbili
Specialized ribosomes: implications for protein synthesis, cell behaviour and health   Johannes Grillari Fabian Nagelreiter
Extracellular vesicle trafficking in aging   Johannes Grillari Vera Pils
Partitioning of virus-like particles and protein superstructures in charged hydrogels   Alois Jungbauaer Patricia Aguilar
Understanding and controlling the expression of recombinant oligomeric immunoglobulins   Renate Kunert Julia Hennicke
In silico guided humanization of antibodies   Renate Kunert Linda Schwaigerlehner
Defined gp140 trimers as HIV vaccine   Renate Kunert Patrick Mundsperger
Engineering Pichia pastoris for antibody surface display   Diethard Mattanovich Lina Heistinger
Characterization of microbial methanol metabolism   Diethard Mattanovich Domen Zavec
Metabolic engineering of Pichia pastoris   Diethard Mattanovich Thomas Gassler
Cellular Mechanisms of Regulation   Brigitte Gasser Sonakshi De
Characterization of transcriptional regulatory proteins   Brigitte Gasser Diane Barbay
Rational systems design of protein-producing yeasts: eliminating metabolic limitations   Brigitte Gasser David Pena
Genomic and epigenomic analysis of a plant-based expression platform for recombinant glycoproteins   Heinz Himmelbauer Matteo Schiavinato
Engineering of T-cell receptor for bispecificity   Florian Rüker Flavio Sadio
Extracellular vesicles as tool for drug delivery   Florian Rüker Stefan Vogt
Enzyme scaffolding and cellular compartments for metabolic engineering endeavours   Michael Sauer Bernd Albrecht
Understanding molecular transport processes for improved metabolic engineering approaches   Michael Sauer Dominik Jeschek
Protein-liposome conjugates as novel HIV vaccine candidates   Karola Vorauer-Uhl Ehsan Suleiman
       
Department of Chemistry      
Enzymatic isotope−labeling of O-glycans for improved tumor biomarker analysis   Friedrich Altmann Johannes Fuehrer
Structural and functional characterisation of a novel bacterial peroxidase with homology to human heme peroxidases   Christian Obinger Andrea Nicolussi
Divergent evolution of the CDE superfamily − analysis of the structural and functional relationship between chlorite dismutases and dye-decolorizing peroxidases   Christian Obinger Vera Pfanzagl
Biochemistry of invertebrate peroxidasins   Christian Obinger Benjamin Sevcnikar
Developing rcSso7d-based chimeric antigen receptors   Christian Obinger Charlotte Brey
Developing rcSso7d-based inhibitory receptors for improving the specificity and safety of NKG2D-CAR-T cells   Christian Obinger Benjamin Salzer
Characterisation of unusual glycosyltransferases from lower eukaryotes   Iain Wilson Barbara Eckmair
       
Department of Food Science and Technology      
Investigation of cellobiose dehydrogenase and lytic polysaccharide monooxygenase for application in industry   Dietmar Haltrich Marita Preims
Recreation of ancestral members of the GMC family of FAD-dependent oxidoreductases   Dietmar Haltrich Leander Sützl
Structure⁄function relationships in the electron transfer reactions of cellobiose dehydrogenase   Dietmar Haltrich Georg Schütz
Structural characterization of Z-disk complex   Dietmar Haltrich Antonio Sponga
Mechanism and dynamics of extracellular cellulolytic protein interactions   Roland Ludwig Christophe Laurent
Development of high-throughput-screening of flavin- and heme-dependent oxidoreductases using genetically encoded redox sensors   Clemens Peterbauer Peter Herzog
       
Department of Material Sciences and Process Engineering      
Advanced molecular modeling tools to quantify protein-protein interactions   Chris Oostenbrink Manuela Maurer
Efficient free energy and enhanced sampling calculations of protein-protein interactions   Chris Oostenbrink Zuzana Jandova
Modelling and simulations of glycosylated proteins   Chris Oostenbrink Aysegül Turupcu
Changing the substrate specifity of lytic polysaccharide monooxygeanse   Chris Oostenbrink Erik Breslmayr
       
Department of NanoBiotechnology      
Oral health: Development of genetic tools for Selenomonas sputigena to unravel mechanisms of dental plaque colonization   Christina Schäffer Susanne Bloch
Structure−function analysis of a phylum-wide conserved glycosyltransferase central to a novel protein O−glycosylation pathway   Christina Schäffer Matthias Braun
Molecular basis of pyruvylated cell wall polymer – SLH-protein interactions   Christina Schäffer Fiona Hager

 

 

List of completed PhD research projects sorted by department:

DEPARTMENT   SUPERVISOR PhD STUDENT
Applied Genetics and Cell Biology      
Antibody production in seed tissues: evaluating the subcellular deposition, N−glycan modification and functionality   Eva Stöger Stanislav Melnik
MAPK and JAK/STAT Signaling in Immune Regulation by Dendritic Cells   Lukas Mach Klara Soukup
Artificial storage organelles for the optimal production of biopharmaceuticals in plants and plant cells   Eva Stöger Anna Hofbauer
Isolation and functional characterization of Nicotiana benthamiana papain-like cysteine proteinases   Lukas Mach Melanie Niemer
       
Department of Biotechnology      
Generation and presentation of membrane protein targets using baculovirus surface display   Reingard Grabherr Monika Wilde
Investigation and Enhancement of Growth Characteristics of Chinese Hamster Ovary Cells   Nicole Borth Gerald Klanert
Cross−Species Comparison of Expression Systems   Reingard Grabherr Andreas Maccani
Influenza virus−like particles as antigen carrier platform for conserved influenza viral epitopes   Reingard Grabherr Miriam Klausberger
Directed evolution of CHO host and production cell lines   Johannes Grillari Eva Harreither
MicroRNOMics of CHO host and production cell lines   Johannes Grillari Vaibhav Jadhav
Influence of surface curvature on unfolding of proteins on nanoparticle   Alois Jungbauer Peter Satzer
Regulation of the expression of recombinant pentameric IgMs   Renate Kunert Veronika Chromikova
Powerful expression of recombinant proteins   Renate Kunert Wolfgang Sommeregger
Influence of amino acid sequence on growth and secretion of recombinant CHO cell lines   Renate Kunert Patrick Mayrhofer
Regulation of heterologous protein production in relation to cell growth   Diethard Mattanovich Corinna Rebnegger
Interrelation of core metabolism with the production of heterologous proteins in yeast   Diethard Mattanovich Justyna Nocon
Modelling of interactions in miRNA and gene expression and target validation   Christian Obinger Smriti Shridhar
       
Department of Chemistry      
Structural and functional characterization of Fcab-antigen interaction   Christian Obinger Elisabeth Lobner
Comparative structural and functional studies on chlorite dismutases and DyP-type peroxidases   Christian Obinger Irene Schaffner
Receptor specificity of the H1 hemagglutinin of the H1N1 swine−origin influenza A virus (S-OIV)   Friedrich Altmann Laura Neumann
Yeast Cell Wall Characterisation   Gunda Köllensperger Evelyn Rampler
Quantitative Metabolomics by LC–MS   Gunda Köllensperger Karin Ortmayr
Functional studies on catalase-peroxidases and design of mechanism-based inhibitors   Christian Obinger Bernhard Gasselhuber
Human peroxidasins − new multidomain oxidoreductases in the vascular system   Christian Obinger Monika Soudi
Biocatalysis of chlorite dismutation − functional and structural studies on new peculiar heme enzymes of high practical relevance for bioremediation   Christian Obinger Stefan Hofbauer
New generations of monoclonal antibodies based on the Fc-fragment of IgG1 − loop engineering and library design of immunoglobulin domains   Christian Obinger Christoph Hasenhindl
Engineering the interface of Fab fragments   Christian Obinger Sylvia Dietrich
Expression cloning of immunomodulatory glycan−modifying enzymes in insect cells   Iain Wilson Simone Kurz
       
Department of Food Science and Technology      
Directed Evolution of a Beta-Galactosidase into a Transgalactosidase   Dietmar Haltrich Barbara Geiger
Probing the active site of pyranose dehydrogenase − covalent attachment of the FAD and vicinity of the isoalloxazine   Dietmar Haltrich Michael Graf
Engineering of pyranose oxidoreductases for modified oxygen reactivity   Dietmar Haltrich Iris Krondorfer
Dagmar Brugger
Establishing platforms for the production of recalcitrant proteins for functional and structural studies   Dietmar Haltrich Georg Mlynek
Engineering of a novel fungal esterase by means of directed evolution and site-directed mutagenesis   Dietmar Haltrich Daniel Kracher
Evolution and engineering of pyranose dehydrogenase for biofuel cell applications   Dietmar Haltrich Christoph Gonaus
Development of food-grade gene expression vectors in lactic acid bacteria   Dietmar Haltrich Minh Nguyen
       
Department of Material Sciences and Process Engineering      
Contribution of enthalpy and entropy in molecular association   Chris Oostenbrink Balder Lai
Structure and dynamics of cellobiose dehydrogenase and cytochrome P450   Chris Oostenbrink Gabor Nagy
       
Department of NanoBiotechnology      
Glycoprofiling of oral pathogens – identification of novel glycoproteins and impact of glycosylation on biofilm formation   Christina Schäffer Cornelia Rath
S−layer mediated display of customized glycans enabled by glycosylation engineering   Christina Schäffer Julia Anzengruber
Assembly and interaction mechanisms of S−layer glycoproteins for applications in nanobiotechnology   Paul Messner Zoe Megson
Carbohydrate−active enzymes in S−layer protein glycosylation   Paul Messner Valentin Friedrich
Biochemical and Molecular Analysis of the Cell Wall Glyco(prote)ome of Lactobacillus buchneri   Paul Messner Eva Smolar
Glycoprofiling of the oral pathogen Tannerella forsythia for identifying novel strategies in pathogenicity   Christina Schäffer Markus Tomek