Projects of Area 2 - Biosynthesis, post-translational modifications and trafficking of recombinant proteins




List of ongoing PhD research projects:

RESEARCH PROJECT   SUPERVISOR PhD STUDENT
Structure and Function of Hexosaminidases   Iain Wilson Zuzanna Dutkiewicz
Enzymatic properties and evolutionary origin of the cancer-associated protease cathepsin O   Lukas Mach Nikolaus Kienzl
Development of selective inhibitors for plant subtilisin-like serine proteases   Lukas Mach Janet Bakalarz
Methylated N-glycans in moss – annoying or useful for biotechnology?   Friedrich Altmann David Stenitzer
Nsun5 methylates rRNA: 'specialized' ribosomes in stress resistance and aging   Johannes Grillari Anja Wagner
Enzymatic isotope−labeling of O-glycans for improved tumor biomarker analysis   Friedrich Altmann Johannes Fuehrer
Extracellular vesicle trafficking in aging   Johannes Grillari Madhusudan Bobbili
Specialized ribosomes: implications for protein synthesis, cell behaviour and health   Johannes Grillari Fabian Nagelreiter
Extracellular vesicle trafficking in aging   Johannes Grillari Vera Pils
Isolation and functional characterization of Nicotiana benthamiana serine proteinases involved in the degradation of recombinant proteins   Lukas Mach Alejandro Puchol Tarazona
Identification of Lewis a containing glycoproteins from Arabidopsis thaliana and characterization of their involvement in pathogen defence   Richard Strasser Gernot Beihammer
Characterisation of unusual glycosyltransferases from lower eukaryotes   Iain Wilson Barbara Eckmair


List of completed PhD research projects:
RESEARCH PROJECT   SUPERVISOR PhD STUDENT
Analysis of structure−function relationships of monomeric and dimeric human IgA1 and IgA2 with defined N− and O−glycosylation   Richard Strasser Kathrin Göritzer
Engineering the interface of Fab fragments for the generation of bispecific antibodies   Johannes Grillari Maximilian Bönisch
Receptor specificity of the H1 hemagglutinin of the H1N1 swine−origin influenza A virus (S-OIV)   Friedrich Altmann Laura Neumann
Isolation and functional characterization of Nicotiana benthamiana papain-like cysteine proteinases   Lukas Mach Melanie Niemer
MAPK and JAK/STAT Signaling in Immune Regulation by Dendritic Cells   Lukas Mach Klara Soukup
Expression cloning of immunomodulatory glycan−modifying enzymes in insect cells   Iain Wilson Simone Kurz