Alumni
Project: Partitioning of virus-like particles and protein superstructures in charged hydrogels
Supervisor: Alois Jungbauer
Project: Enzyme scaffolding and cellular compartments for metabolic engineering endeavours
Supervisor: Michael Sauer
Project: Glycosylation engineering of S-layer proteins for bioactivity
Supervisor: Christina Schäffer
Project: Characterization of transcriptional regulatory proteins
Supervisor: Brigitte Gasser
Project: Increasing efficiency of CO2 assimilation in synthetic autotrophic Pichia pastoris
Supervisor: Diethard Mattanovich
Project: Identification of Lewis a containing glycoproteins from Arabidopsis thaliana and characterization of their involvement in pathogen defence
Supervisor: Richard Strasser
Project: Bispecific antibodies with monovalent antigen engagement in the Fc domain
Supervisor: Florian Rüker
Project: Oral health: Development of genetic tools for Selenomonas sputigena to unravel mechanisms of dental plaque colonization
Supervisor: Christina Schäffer
Project: Extracellular vesicle trafficking in aging
Supervisor: Johannes Grillari
Project: Biochemical and Molecular Analysis of the Cell Wall Glyco(prote)ome of Lactobacillus buchneri
Supervisor: Paul Messner
Project: Engineering the interface of Fab fragments for the generation of bispecific antibodies
Supervisor: Johannes Grillari
Project: Structure−function analysis of a phylum-wide conserved glycosyltransferase central to a novel protein O−glycosylation pathway
Joint-Supervisors: Christina Schäffer and Friedrich Altmann
Project: Changing the substrate specifity of lytic polysaccharide monooxygeanse
Joint-Supervisors: Roland Ludwig and Chris Oostenbrink
Project: Developing rcSso7d-based chimeric antigen receptors
Supervisor: Christian Obinger
Project: Engineering of pyranose oxidoreductases for modified oxygen reactivity
Supervisor: Dietmar Haltrich
Project: Understanding the source of variation in protein N-glycosylation patterns of recombinant proteins generated in CHO cells
Joint-Supervisors: Nicole Borth and Richard Strasser
Project: Regulation of expression of recombinant pentameric IgM
Supervisor: Renate Kunert
Project: Allosteric molecular recognition to improve tumor specificity
Supervisor: Michael Traxlmayr
Project: Characterisation of unusual glycosyltransferases from lower eukaryotes
Supervisor: Iain Wilson
Project: Engineering and functional activities of polysialylated IgG antibodies
Supervisor: Herta Steinkellner
Project: Productivity optimisation of CHO cells by epigenome alterations
Supervisor: Nicole Borth
Project: Enzymatic isotope−labeling of O-glycans for improved tumor biomarker analysis
Supervisor: Friedrich Altmann
FRIEDRICH Valentin
Project: Carbohydrate-active enzymes in S-layer protein glycosylation
Supervisor: Paul Messner
Project: Biochemistry of firmicute coproporphyrin ferrochelatase from Listeria monocytogenes
Supervisor: Stefan Hofbauer
Project: Functional studies on catalase-peroxidases and design of mechanism-based inhibitor
Supervisor: Christian Obinger
Project: Directed Evolution of a Beta-Galactosidase into a Transgalactosidase
Supervisor: Dietmar Haltrich
GÖRITZER Kathrin
Project: Analysis of structure−function relationships of monomeric and dimeric human IgA1 and IgA2 with defined N− and O−glycosylation
Joint-Supervisors: Richard Strasser, Christian Obinger and Rupert Tscheliessnig
Project: Evolution and engineering of pyranose dehydrogenase for biofuel cell applications
Supervisor: Dietmar Haltrich
Project: Thermodynamics for allosteric modulation
Supervisor: Chris Oostenbrink
Project: Seasonal influenza virus vaccine effectiveness through recombinant neuraminidase on VLPs
Joint-Supervisors: Reingard Grabherr and Alois Jungbauer
Project: Molecular basis of pyruvylated cell wall polymer – SLH-protein interactions
Supervisor: Christina Schäffer
Project: New generations of monoclonal antibodies based on the Fc-fragment of IgG1
Supervisor: Christian Obinger
Project: Inducible regulation of baculovirus genes involved in secretion and virus budding
Supervisor: Reingard Grabherr
Project: Engineering Pichia pastoris for antibody surface display
Supervisor: Diethard Mattanovich
Project: Understanding and controlling the expression of recombinant oligomeric immunoglobulins
Supervisor: Renate Kunert
Project: Mechanistic synergism between bacterial pyranose oxidase and peroxidase in lignin depolymerization
Joint-Supervisors: Chris Oostenbrink and Clemens Peterbauer
Project: Genomic rearrangements in CHO producer cell lines
Supervisor: Nicole Borth
HERZOG Peter
Project: Development of high-throughput-screening of flavin- and heme-dependent oxidoreductases using genetically encoded redox sensors
Joint-Supervisors: Clemens Peterbauer and Christian Obinger
Project: Artificial storage organelles for the optimal production of biopharmaceuticals in plants and plant cells
Supervisor: Eva Stöger
Project: Impact of cellular redox state on protein production and secretion in yeast
Joint-Supervisors: Brigitte Gasser and Jürgen Zanghellini
Project: MicroRNOMics of CHO host and production cell lines
Supervisor: Johannes Grillari
Project: Protein solubility in buffers with kosmotropic salts and polyols
Supervisor: Alois Jungbauer
Project: Efficient free energy and enhanced sampling calculations of protein-protein interactions
Supervisor: Chris Oostenbrink
Project: Understanding molecular transport processes for improved metabolic engineering approaches
Supervisor: Michael Sauer
Project: Plant glyco-engineering towards synthesis of recombinant proteins with polysialylated N-glycans
Supervisor: Herta Steinkellner
Project: Enzymatic properties and evolutionary origin of the cancer-associated protease cathepsin O
Joint-Supervisors: Lukas Mach and Dietmar Haltrich
KLANSCHNIG Marco
Project: Understand and exploit sigma-appropriation as a tool for transcription control in E. coli
Supervisor: Reingard Grabherr
Project: Influenza virus-like particles as antigen carrier platform for conserved influenza viral epitopes
Supervisor: Reingard Grabherr
Project: Investigation and Enhancement of Growth Characteristics of Chinese Hamster Ovary Cells
Supervisor: Nicole Borth
Project: Molecular engineering of baculoviral based protein expression in insect cells
Supervisor: Reingard Grabherr
Project: Increasing thermostability of pyranose oxidase by enzyme evolution
Supervisor: Dietmar Haltrich
Project: Engineering of a novel fungal esterase by means of directed evolution and site-directed mutagenesis
Supervisor: Dietmar Haltrich
Project: Engineering of pyranose oxidoreductases for modified oxygen reactivity
Supervisor: Dietmar Haltrich
Project: Expression cloning of immunomodulatory glycan-modifying enzymes in insect cells
Supervisor: Iain Wilson
Project: Contribution of enthalpy and entropy in molecular association
Supervisor: Chris Oostenbrink
Project: Mechanism and dynamics of extracellular cellulolytic protein interactions
Joint-Supervisors: Chris Oostenbrink and Roland Ludwig
Project: Structural and functional characterization of Fcab-antigen interaction
Supervisor: Christian Obinger
Project: Advanced molecular modeling tools to quantify protein-protein interactions
Supervisor: Chris Oostenbrink
Project: Influence of amino acid sequence on growth and secretion of recombinant CHO cell lines
Supervisor: Renate Kunert
Project: Assembly and interaction mechanisms of S-layer glycoproteins for applications in nanobiotechnology
Supervisor: Paul Messner
Project: Antibody production in seed tissues: evaluating their subcellular deposition, N-glycan modification and functionality
Supervisor: Eva Stöger
Project: Biochemistry of actinobacterial coproheme decarboxylase (ChdC) from Corynebacterium diphteriae
Supervisor: Christian Obinger
MITIC Bernd
Project: Advanced analytical strategies for investigation of alternative methanol assimilation in methylotrophic yeasts
Joint-Supervisors: Stephan Hann and Diethard Mattanovich
Project: Establishing platforms for the production of recalcitrant proteins for functional and structural studies
Supervisor: Dietmar Haltrich
Project: Immunoglobulin E (IgE) and glycosylation
Supervisor: Herta Steinkellner
Project: Resolving dynamic protein conformations in multidomain enzymes with SAXS
Joint-Supervisors: Roland Ludwig and Rupert Tscheliessnig
Project: Specialized ribosomes: implications for protein synthesis, cell behaviour and health
Supervisor: Johannes Grillari
Project: Structure and dynamics of cellobiose dehydrogenase and cytochrome P450
Supervisor: Chris Oostenbrink
Project: Receptor specificity of the H1 haemagglutinin of the H1N1 swine-origin influenza A virus (S-OIV)
Supervisor: Friedrich Altmann
Project: Development of food-grade gene expression vectors in lactic acid bacteria
Supervisor: Dietmar Haltrich
Project: Structural and functional characterisation of a novel bacterial peroxidase with homology to human heme peroxidases
Supervisor: Christian Obinger
Project: Isolation and functional characterization of Nicotiana benthamiana papain-like cysteine proteinases
Supervisor: Lukas Mach
Project: Generation and presentation of membrane protein targets using influenza virus−like particles
Supervisor: Reingard Grabherr
Project: Interrelation of core metabolism with the production of heterologous proteins in yeast
Supervisor: Diethard Mattanovich
PENA NAVARRO David
Project: Rational systems design of protein-producing yeasts: eliminating metabolic limitations
Joint-Supervisors: Brigitte Gasser and Jürgen Zanghellini
Project: Extracellular Vesicles: Proteome, miRnome and influence on stem cells
Supervisor: Johannes Grillari
Project: Investigation of cellobiose dehydrogenase and lytic polysaccharide monooxygenase for application in industry
Supervisor: Dietmar Haltrich
Project: Isolation and functional characterization of Nicotiana benthamiana serine proteinases involved in the degradation of recombinant proteins
Supervisor: Lukas Mach
Project: Glycoprofiling of oral pathogens – identification of novel glycoproteins and impact of glycosylation on biofilm formation
Supervisor: Christina Schäffer
Project: Regulation of heterologous protein production in relation to cell growth
Supervisor: Diethard Mattanovich
Project: Engineering of Cellobiose Dehydrogenase for Glucose Biosensors
Supervisor: Roland Ludwig
Project: Engineering of a bispecific mAb recognizing an optimized epitope of IgE as well as CD3 – a novel strategy for fighting allergic diseases
Joint-Supervisors: Florian Rüker and Fritz Altmann
Project: Synthetic biology tools to control expression of multiple genes in a pathway
Supervisor: Nicole Borth
Project: Effects of N-glycans on structure and dynamics of IgAs and their implications on receptor binding
Joint-Supervisors: Richard Strasser and Rupert Tscheließnig
SADIO Flavio
Project: Engineering of T-cell receptor for bispecificity
Supervisor: Florian Rüker
Project: Developing rcSso7d-based inhibitory receptors for improving the specificity and safety of NKG2D-CAR-T cells
Supervisor: Christian Obinger
Project: Influence of surface curvature on unfolding of proteins on nanoparticles
Supervisor: Alois Jungbauer
Project: Routing the flow of electron from cytochromes to oxidoreductases
Supervisor: Roland Ludwig
Project: Comparative structural and functional studies on chlorite dismutases and DyP-type peroxidases
Supervisor: Christian Obinger
Project: Genomic and epigenomic analysis of a plant-based expression platform for recombinant glycoproteins
Joint-Supervisors: Heinz Himmelbauer and Lukas Mach
Project: Structural and mechanistic studies on chlorite dismutase (Cld) from Cyanothece sp. PCC7425
Supervisor: Christian Obinger
SCHÜTZ Georg
Project: Structure-function relationships in the electron transfer reactions of cellobiose dehydrogenase
Supervisor: Dietmar Haltrich
Project: Cytochromes as electron transfer mediators for bioelectrodes
Supervisor: Roland Ludwig
Project: In silico guided humanization of antibodies
Supervisor: Renate Kunert
Project: Designed protein storage organelles and their uptake into target cells
Supervisor: Eva Stöger
Project: The cancer immunotherapy antigen CD19 and its molecular interaction network
Joint-Supervisors: Christian Obinger and Renate Kunert
Project: Modelling of interactions in microRNA and gene expression and validation of predicted targets
Supervisor: David Kreil
Project: Human peroxidasins – new multidomain oxidoreductases in the vascular system
Supervisor: Christian Obinger
Project: MAPK and JAK/STAT Signaling in Immune Regulation by Dendritic Cells
Supervisor: Lukas Mach
Project: Structural characterization of Z-disk complex
Supervisor: Dietmar Haltrich
Project: Secondary cell wall polymer pyruvylation as an essential ligand modification for SLH-domain recognition
Supervisor: Christina Schäffer
Project: Methylated N-glycans in moss – annoying or useful for biotechnology?
Supervisor:Friedrich Altmann
Project: Recreation of ancestral members of the GMC family of FAD-dependent oxidoreductases
Supervisor: Dietmar Haltrich
Project: Protein-liposome conjugates as novel HIV vaccine candidates
Supervisor: Karola Vorauer-Uhl
Project: Engineering a small molecule regulated heterodimerization system for the control of CAR T cells
Joint-Supervisors: Chris Oostenbrink and Christian Obinger
Project: Introduction of unnatural amino acids in recombinant proteins with the yeast Pichia pastoris
Supervisor: Diethard Mattanovich
Project: Glycoprofiling of the oral pathogen Tannerella forsythia for identifying novel strategies in pathogenicity
Supervisor: Christina Schäffer
Project: Development of a seed-based strategy for the design of a mucosal vaccine against S. pneumoniae
Supervisor: Eva Stöger
Project: Novel Lactate-Oxidizing Enzymes for Biosensor Applications
Supervisor: Dietmar Haltrich
Project: Modelling and simulations of glycosylated proteins
Supervisor: Chris Oostenbrink
Project: O-glycan engineering of N. benthamiana for structure-function characterization of human IgA1
Joint-Supervisors: Eva Stöger and Richard Strasser
Project: Design of a minimal enzyme set for lignin depolymerization
Joint-Supervisors: Michael Sauer and Clemens Peterbauer
Project: Accessory Activities 3: Novel Flavoprotein Oxidoreductase from bacterial sources
Supervisor: Clemens Peterbauer
Project: Extracellular vesicles as tool for drug delivery
Supervisor: Florian Rüker
Project: Nsun5 methylates rRNA: 'specialized' ribosomes in stress resistance and aging
Supervisor: Johannes Grillari
Project: Change of the Global Methylation Pattern to Alter the Growth Phenotype of CHO-Cells
Supervisor: Nicole Borth
Project: Generation and presentation of membrane protein targets using baculovirus surface display
Supervisor: Reingard Grabherr
Project: Effect of membrane organization on weak acid transport proteins
Joint-Supervisors: Karola Vorauer-Uhl and Michael Sauer
BioToP Project: Characterization of microbial methanol metabolism
Supervisor: Diethard Mattanovich